Tetrahydrofuran → 2-(4-Acetyl-2-methylphenyl)-2-methylpropanenitrile

HRID 804916Notes

Reaction equation

HRID 804916 reaction equation
[Br:1][c:2]1[cH:3][c:4]([CH3:13])[c:5]([C:8]([C:9]#[N:10])([CH3:11])[CH3:12])[cH:6][cH:7]1.[CH2:14]([Li:15])[CH2:16][CH2:17][CH3:18].[CH2:26]1[O:27][CH2:28][CH2:29][CH2:30]1.[CH3:19][O:20][N:21]([C:22]([CH3:23])=[O:24])[CH3:25]>>[c:2]1([C:22]([CH3:23])=[O:24])[cH:3][c:4]([CH3:13])[c:5]([C:8]([C:9]#[N:10])([CH3:11])[CH3:12])[cH:6][cH:7]1

Participants

5

Reactant 4

HCID 8028TetrahydrofuranHCID 537505N-Methoxy-N-methylacetamideHCID 582984672-(4-Bromo-2-methylphenyl)-2-methylpropanenitrileHCID 178418339Butyllithium

Product 1

HCID 582984812-(4-Acetyl-2-methylphenyl)-2-methylpropanenitrile

Sources & evidence

ORD record
ord-1172b5facf604225b8816a722dd6eaf8
Source dataset
Test data from https://doi.org/10.1039/C8SC04228D

Reaction notes

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