Acetonitrile → [2-Methoxy-5-(tetrazol-1-yl)phenyl]-[3-[2-[4-(1-pentylbenzimidazol-2-yl)-1,4-diazepan-1-yl]ethyl]-3-phenylpyrrolidin-1-yl]methanone

HRID 805059Notes

Reaction equation

HRID 805059 reaction equation
[CH3:24][O:25][c:26]1[c:27]([C:37](=[O:38])[N:39]2[CH2:40][C:41]([c:44]3[cH:45][cH:46][cH:47][cH:48][cH:49]3)([CH2:50][CH2:51][O:52][S:53]([CH3:54])(=[O:55])=[O:56])[CH2:42][CH2:43]2)[cH:28][c:29](-[n:32]2[n:33][n:34][n:35][cH:36]2)[cH:30][cH:31]1.[CH3:66][C:67]#[N:68].[CH:57]([N:58]([CH:59]([CH3:60])[CH3:61])[CH2:62][CH3:63])([CH3:64])[CH3:65].[IH:1].[IH:2].[N:3]1([c:10]2[n:11][c:12]3[c:13]([n:14]2[CH2:15][CH2:16][CH2:17][CH2:18][CH3:19])[cH:20][cH:21][cH:22][cH:23]3)[CH2:4][CH2:5][NH:6][CH2:7][CH2:8][CH2:9]1>>[N:3]1([c:10]2[n:11][c:12]3[c:13]([n:14]2[CH2:15][CH2:16][CH2:17][CH2:18][CH3:19])[cH:20][cH:21][cH:22][cH:23]3)[CH2:4][CH2:5][N:6]([CH2:51][CH2:50][C:41]2([c:44]3[cH:45][cH:46][cH:47][cH:48][cH:49]3)[CH2:40][N:39]([C:37]([c:27]3[c:26]([O:25][CH3:24])[cH:31][cH:30][c:29](-[n:32]4[n:33][n:34][n:35][cH:36]4)[cH:28]3)=[O:38])[CH2:43][CH2:42]2)[CH2:7][CH2:8][CH2:9]1

Participants

6

Reactant 5

HCID 6342AcetonitrileHCID 24841Hydrogen iodide2×HCID 81531DiisopropylethylamineHCID 18464588HCID 18464588, compoundHCID 184648112-methoxy-5-(1H-tetrazol-1-yl)benzoyl-3-phenyl-3-(2-methanesulfonyloxyethyl)-pyrrolidine

Product 1

HCID 18464621[2-Methoxy-5-(tetrazol-1-yl)phenyl]-[3-[2-[4-(1-pentylbenzimidazol-2-yl)-1,4-diazepan-1-yl]ethyl]-3-phenylpyrrolidin-1-yl]methanone

Sources & evidence

ORD record
ord-c67d584d9cf441a08609ff6420aa94e8
Source dataset
Test data from https://doi.org/10.1039/C8SC04228D

Reaction notes

Loading…