Dimethylformamide → cyclopropyl(4-((2-hydroxyethyl)(phenyl)amino)-2-(4-(oxazol-5-yl)phenylamino)-7,8-dihydropyrido[4,3-d]pyrimidin-6(5H)-yl)methanone

HRID 805213Notes

Reaction equation

HRID 805213 reaction equation
[CH:33]1([C:36](=[O:37])[Cl:38])[CH2:34][CH2:35]1.[O:39]=[CH:40][N:41]([CH3:42])[CH3:43].[o:1]1[cH:2][n:3][cH:4][c:5]1-[c:6]1[cH:7][cH:8][c:9]([NH:12][c:13]2[n:14][c:15]([N:23]([CH2:24][CH2:25][OH:26])[c:27]3[cH:28][cH:29][cH:30][cH:31][cH:32]3)[c:16]3[c:17]([n:18]2)[CH2:19][CH2:20][NH:21][CH2:22]3)[cH:10][cH:11]1>>[o:1]1[cH:2][n:3][cH:4][c:5]1-[c:6]1[cH:7][cH:8][c:9]([NH:12][c:13]2[n:14][c:15]([N:23]([CH2:24][CH2:25][OH:26])[c:27]3[cH:28][cH:29][cH:30][cH:31][cH:32]3)[c:16]3[c:17]([n:18]2)[CH2:19][CH2:20][N:21]([C:36]([CH:33]2[CH2:34][CH2:35]2)=[O:37])[CH2:22]3)[cH:10][cH:11]1

Participants

4

Reactant 3

HCID 6228DimethylformamideHCID 77637Cyclopropanecarbonyl chlorideHCID 462000502-((2-(4-(Oxazol-5-yl)phenylamino)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4-yl)(phenyl)amino)ethanol

Product 1

HCID 46200511cyclopropyl(4-((2-hydroxyethyl)(phenyl)amino)-2-(4-(oxazol-5-yl)phenylamino)-7,8-dihydropyrido[4,3-d]pyrimidin-6(5H)-yl)methanone

Sources & evidence

ORD record
ord-012708acdc91472b85c3e387ffb3eba4
Source dataset
Test data from https://doi.org/10.1039/C8SC04228D

Reaction notes

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