Benzyl Bromide → 3-Benzyl-7-oxo-6,7-dihydro-5h-pyrido[3,4-d][2]benzazepin-3-ium bromide

HRID 80522Notes

Reaction equation

HRID 80522 reaction equation
[CH:1]1[C:11]2[C:10]3[CH:12]=[CH:13][CH:14]=[CH:15][C:9]=3[C:8](=[O:16])[NH:7][CH2:6][C:5]=2[CH:4]=[N:3][CH:2]=1.[CH2:17]([Br:24])[C:18]1[CH:23]=[CH:22][CH:21]=[CH:20][CH:19]=1>C(O)C>[Br-:24].[CH2:17]([N+:3]1[CH:2]=[CH:1][C:11]2[C:10]3[CH:12]=[CH:13][CH:14]=[CH:15][C:9]=3[C:8](=[O:16])[NH:7][CH2:6][C:5]=2[CH:4]=1)[C:18]1[CH:23]=[CH:22][CH:21]=[CH:20][CH:19]=1

Participants

4

Reactant 2

HCID 7498Benzyl BromideHCID 59548516HCID 59548516, compound

Product 1

HCID 672477733-Benzyl-7-oxo-6,7-dihydro-5h-pyrido[3,4-d][2]benzazepin-3-ium bromide

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

A mixture of Example 180D (24.6 g, 0.117 mol) and benzyl bromide (40.1 g, 0.234 mol) in 200 mL of ethanol was stirred at reflux overnight. After cooling with an ice-water bath, the solid was collected by filtration and washed with ethanol to obtain the title compound.

Workup

  1. temperatureat reflux overnight
  2. temperatureAfter cooling with an ice-water bath
  3. filtrationthe solid was collected by filtration
  4. washwashed with ethanol

Sources & evidence

ORD record
ord-be39230d9547409f9ab4da7497a16110
Source dataset
uspto-grants-2014_09
Patent number
US08846663B2

Reaction notes

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