Acetate → 2-Fluoro-4-[7-(1-quinolin-6-ylethyl)imidazo[1,2-b][1,2,4]triazin-2-yl]benzonitrile

HRID 805436Notes

Reaction equation

HRID 805436 reaction equation
[Br:1][c:2]1[c:3]([F:29])[cH:4][c:5](-[c:8]2[cH:9][n:10][c:11]3[n:12]([n:13]2)[c:14]([CH:17]([CH3:18])[c:19]2[cH:20][c:21]4[cH:22][cH:23][cH:24][n:25][c:26]4[cH:27][cH:28]2)[cH:15][n:16]3)[cH:6][cH:7]1.[C:48]([O-:49])(=[O:50])[CH3:51].[C:53]([O-:54])(=[O:55])[CH3:56].[CH3:36][N:37]([CH3:38])[C:39](=[O:40])[CH3:41].[CH3:42][CH2:43][O:44][C:45]([CH3:46])=[O:47].[Na+:30].[Na+:31].[O-:32][C:33](=[O:34])[O-:35].[Pd+2:52]>>[c:2]1([C:36]#[N:37])[c:3]([F:29])[cH:4][c:5](-[c:8]2[cH:9][n:10][c:11]3[n:12]([n:13]2)[c:14]([CH:17]([CH3:18])[c:19]2[cH:20][c:21]4[cH:22][cH:23][cH:24][n:25][c:26]4[cH:27][cH:28]2)[cH:15][n:16]3)[cH:6][cH:7]1

Participants

8

Reactant 7

HCID 175Acetate2×HCID 923Sodium ion2×HCID 8857Ethyl AcetateHCID 19660Carbonate IonHCID 31374DimethylacetamideHCID 105144Allyl(1,3-bis(2,6-diisopropylphenyl)imidazol-2-ylidene)chloropalladium(II)HCID 672243466-1-[2-(4-Bromo-3-fluorophenyl)imidazo[1,2-b][1,2,4]triazin-7-yl]ethylquinoline

Product 1

HCID 672248682-Fluoro-4-[7-(1-quinolin-6-ylethyl)imidazo[1,2-b][1,2,4]triazin-2-yl]benzonitrile

Sources & evidence

ORD record
ord-6ce12664f18c49fd86452e72be4cf463
Source dataset
Test data from https://doi.org/10.1039/C8SC04228D

Reaction notes

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