N-methyl-2-pyrrolidone → Grepafloxacin

HRID 805622Notes

Reaction equation

HRID 805622 reaction equation
[CH3:1][CH:2]1[NH:3][CH2:4][CH2:5][NH:6][CH2:7]1.[CH3:28][N:29]1[CH2:30][CH2:31][CH2:32][C:33]1=[O:34].[CH:8]1([n:11]2[cH:12][c:13]([C:25](=[O:26])[OH:27])[c:14](=[O:24])[c:15]3[c:16]([CH3:23])[c:17]([F:22])[c:18]([F:21])[cH:19][c:20]23)[CH2:9][CH2:10]1>>[CH3:1][CH:2]1[NH:3][CH2:4][CH2:5][N:6]([c:18]2[c:17]([F:22])[c:16]([CH3:23])[c:15]3[c:14](=[O:24])[c:13]([C:25](=[O:26])[OH:27])[cH:12][n:11]([CH:8]4[CH2:9][CH2:10]4)[c:20]3[cH:19]2)[CH2:7]1

Participants

4

Reactant 3

HCID 13387N-methyl-2-pyrrolidoneHCID 660572-MethylpiperazineHCID 146512541-Cyclopropyl-6,7-difluoro-5-methyl-4-oxo-1,4-dihydroquinoline-3-carboxylic acid

Product 1

HCID 72474Grepafloxacin

Sources & evidence

ORD record
ord-1bbdccf5b9da440ea6c1c7a2b26a024b
Source dataset
Test data from https://doi.org/10.1039/C8SC04228D

Reaction notes

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