Hydrochloric Acid → HCID 178448360, compound

HRID 80576Notes

Reaction equation

HRID 80576 reaction equation
[NH2:1][C:2]1[CH:14]=[C:13]([C@H:15]([NH:19][C:20]([N:22]2[C:28](=[O:29])[C@@H:27]([CH2:30][C:31]3[CH:36]=[C:35]([Cl:37])[CH:34]=[CH:33][C:32]=3[O:38][CH3:39])[CH2:26][NH:25][C:24](=[N:40][N:41]([CH3:43])[CH3:42])[CH2:23]2)=[O:21])[CH2:16][CH2:17][CH3:18])[CH:12]=[CH:11][C:3]=1[C:4]([O:6]C(C)(C)C)=[O:5].Cl.C1(C)C=CC=CC=1>C(O)(=O)C>[NH2:1][C:2]1[CH:14]=[C:13]([C@H:15]([NH:19][C:20]([N:22]2[C:28](=[O:29])[C@@H:27]([CH2:30][C:31]3[CH:36]=[C:35]([Cl:37])[CH:34]=[CH:33][C:32]=3[O:38][CH3:39])[CH2:26][NH:25][C:24](=[N:40][N:41]([CH3:43])[CH3:42])[CH2:23]2)=[O:21])[CH2:16][CH2:17][CH3:18])[CH:12]=[CH:11][C:3]=1[C:4]([OH:6])=[O:5]

Participants

5

Reactant 3

HCID 313Hydrochloric AcidHCID 1140TolueneHCID 178448359HCID 178448359, compound

Product 1

HCID 178448360HCID 178448360, compoundYield 87.3%

Reagents, catalysts & solvents 1

HCID 176Acetic AcidSolvent

Procedure

To the compound 21 (16 mg), 1 M hydrochloric acid in acetic acid solution was added, and the mixture was stirred at room temperature for 4 hours. To the reaction solution, toluene (5 ml) was added and the precipitated solid was collected by filtration to obtain the title compound (12.7 mg).

Workup

  1. filtrationthe precipitated solid was collected by filtration

Sources & evidence

ORD record
ord-fcd5ed3f568e4cf29d9b2b1918b3a1ac
Source dataset
uspto-grants-2014_09
Patent number
US08846660B2

Reaction notes

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