反应详情

To the compound S140c described in WO 06-059801A, that is, (6R)-6-(5-chloro-2-methoxybenzyl)-1-(2,4,6-trimethoxybenzyl)-1,4-diazepane-2,5-dione (2.2 g) in a tetrahydrofuran (80 ml) solution, Belleau's reagent (1.5 g) was added under ice cooling, and the mixture was stirred at that temperature for 3 hours. The reaction solution was diluted with ethyl acetate, successively washed with saturated aqueous sodium hydrogencarbonate solution, water, and brine, dried over anhydrous sodium sulfate, then concentrated. The residue was purified by flash column chromatography (silica gel, hexane/ethyl acetate=35/65 to 1/99) to obtain the title compound (1.69 g).

1. washsuccessively washed with saturated aqueous sodium hydrogencarbonate solution, water, and brine
2. dry with materialdried over anhydrous sodium sulfate
3. concentrationconcentrated
4. customThe residue was purified by flash column chromatography (silica gel, hexane/ethyl acetate=35/65 to 1/99)