Hydrochloric Acid → HCID 178448367, compound

HRID 80594Notes

Reaction equation

HRID 80594 reaction equation
[Cl:1][C:2]1[CH:3]=[CH:4][C:5]([O:55][CH3:56])=[C:6]([CH:54]=1)[CH2:7][C@@H:8]1[C:14](=[O:15])[N:13]([C:16]([NH:18][C@@H:19]([C:23]2[CH:35]=[CH:34][C:26]([C:27]([O:29]C(C)(C)C)=[O:28])=[C:25]([N+:36]([O-:38])=[O:37])[CH:24]=2)[CH2:20][CH2:21][CH3:22])=[O:17])[CH2:12][C:11](=[N:39][OH:40])[N:10](CC2C(OC)=CC(OC)=CC=2OC)[CH2:9]1.Cl>C(OCC)(=O)C>[ClH:1].[Cl:1][C:2]1[CH:3]=[CH:4][C:5]([O:55][CH3:56])=[C:6]([CH:54]=1)[CH2:7][C@@H:8]1[C:14](=[O:15])[N:13]([C:16]([NH:18][C@@H:19]([C:23]2[CH:35]=[CH:34][C:26]([C:27]([OH:29])=[O:28])=[C:25]([N+:36]([O-:38])=[O:37])[CH:24]=2)[CH2:20][CH2:21][CH3:22])=[O:17])[CH2:12][C:11](=[N:39][OH:40])[NH:10][CH2:9]1

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 86672202HCID 86672202, compound

Product 1

HCID 178448367HCID 178448367, compound

Reagents, catalysts & solvents 1

HCID 8857Ethyl AcetateSolvent

Procedure

To the compound 97a crude product obtained at Step (1) (10.7 g), a 4M hydrochloric acid in ethyl acetate solution (100 ml) was added, and the mixture was stirred at room temperature for 5.5 hours. The reaction mixture was concentrated until the crystals were precipitated, and the precipitated crystals were collected by filtration to obtain the title compound (1.74 g).

Workup

  1. concentrationThe reaction mixture was concentrated until the crystals
  2. customwere precipitated
  3. filtrationthe precipitated crystals were collected by filtration

Sources & evidence

ORD record
ord-eabbd3d29baf464f9b3b8ea115ec6a6c
Source dataset
uspto-grants-2014_09
Patent number
US08846660B2

Reaction notes

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