Dichloromethane → N-(4,5-Difluoro-2-(hydroxymethyl)phenyl)pivalamide

HRID 805944Notes

Reaction equation

HRID 805944 reaction equation
[CH2:31]1[O:32][CH2:33][CH2:34][CH2:35]1.[CH3:1][C:2]([C:3](=[O:4])[Cl:5])([CH3:6])[CH3:7].[CH:19]([N:20]([CH2:21][CH3:22])[CH:23]([CH3:24])[CH3:25])([CH3:26])[CH3:27].[Cl:28][CH2:29][Cl:30].[NH2:8][c:9]1[c:10]([CH2:17][OH:18])[cH:11][c:12]([F:16])[c:13]([F:15])[cH:14]1>>[CH3:1][C:2]([C:3](=[O:4])[NH:8][c:9]1[c:10]([CH2:17][OH:18])[cH:11][c:12]([F:16])[c:13]([F:15])[cH:14]1)([CH3:6])[CH3:7]

Participants

6

Reactant 5

HCID 6344DichloromethaneHCID 8028TetrahydrofuranHCID 62493Pivaloyl chlorideHCID 81531DiisopropylethylamineHCID 21925570(2-Amino-4,5-difluorophenyl)methanol

Product 1

HCID 59732039N-(4,5-Difluoro-2-(hydroxymethyl)phenyl)pivalamide

Sources & evidence

ORD record
ord-3eb5a1f464bf4b1b9908c7e94a247225
Source dataset
Test data from https://doi.org/10.1039/C8SC04228D

Reaction notes

Loading…