Hydrochloric Acid → 2-(4-Fluorophenyl)-1-(2-((3-methoxy-4-(4-methyl-1H-imidazol-1-yl)phenyl)amino)-6,7-dihydrothiazolo[5,4-c]pyridin-5(4H)-yl)ethanone
Reaction equation
[CH3:4][O:5][c:6]1[cH:7][c:8]([NH:18][c:19]2[s:20][c:21]3[c:26]([n:27]2)[CH2:25][CH2:24][NH:23][CH2:22]3)[cH:9][cH:10][c:11]1-[n:12]1[cH:13][n:14][c:15]([CH3:17])[cH:16]1.[ClH:1].[ClH:2].[ClH:3].[F:28][c:29]1[cH:30][cH:31][c:32]([CH2:35][C:36](=[O:37])[OH:38])[cH:33][cH:34]1.[Na+:69].[O:39]=[CH:40][N:41]([CH3:42])[CH3:43].[OH-:68].[P-:44]([F:45])([F:46])([F:47])([F:48])([F:49])[F:50].[n:51]1([O:52][C:53]([N:54]([CH3:55])[CH3:56])=[N+:57]([CH3:58])[CH3:59])[c:60]2[cH:61][cH:62][cH:63][cH:64][c:65]2[n:66][n:67]1>>[CH3:4][O:5][c:6]1[cH:7][c:8]([NH:18][c:19]2[s:20][c:21]3[c:26]([n:27]2)[CH2:25][CH2:24][N:23]([C:36]([CH2:35][c:32]2[cH:31][cH:30][c:29]([F:28])[cH:34][cH:33]2)=[O:37])[CH2:22]3)[cH:9][cH:10][c:11]1-[n:12]1[cH:13][n:14][c:15]([CH3:17])[cH:16]1Participants
9
Reactant 8
HCID 313Hydrochloric Acid3×
HCID 923Sodium ion
HCID 961Hydroxide
HCID 6228Dimethylformamide
HCID 98372-(4-Fluorophenyl)acetic acid
HCID 9886Hexafluorophosphate
HCID 130500O-benzotriazol-1-yl-tetramethyluronium
HCID 25106281N-[3-methoxy-4-(4-methylimidazol-1-yl)phenyl]-4,5,6,7-tetrahydro-[1,3]thiazolo[5,4-c]pyridin-2-amineProduct 1
Sources & evidence
- ORD record
- ord-cba14edbefd04608889117c3288d308b
- Source dataset
- Test data from https://doi.org/10.1039/C8SC04228D
Reaction notes
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