Chloride → 6-[3-(2-Fluoro-phenyl)-5-methyl-isoxazol-4-ylmethoxy]-nicotinic acid methyl ester

HRID 806219Notes

Reaction equation

HRID 806219 reaction equation
[CH2:31]1[O:32][CH2:33][CH2:34][CH2:35]1.[Cl-:30].[Cl:18][c:19]1[n:20][cH:21][c:22]([C:23](=[O:24])[O:25][CH3:26])[cH:27][cH:28]1.[F:3][c:4]1[c:5](-[c:10]2[n:11][o:12][c:13]([CH3:17])[c:14]2[CH2:15][OH:16])[cH:6][cH:7][cH:8][cH:9]1.[H-:1].[Na+:29].[Na+:2]>>[F:3][c:4]1[c:5](-[c:10]2[n:11][o:12][c:13]([CH3:17])[c:14]2[CH2:15][O:16][c:19]2[n:20][cH:21][c:22]([C:23](=[O:24])[O:25][CH3:26])[cH:27][cH:28]2)[cH:6][cH:7][cH:8][cH:9]1

Participants

7

Reactant 6

HCID 312ChlorideHCID 923Sodium ion2×HCID 8028TetrahydrofuranHCID 166653HydrideHCID 254249Methyl 6-chloropyridine-3-carboxylateHCID 68444673(3-(2-Fluorophenyl)-5-methylisoxazol-4-yl)methanol

Product 1

HCID 684455236-[3-(2-Fluoro-phenyl)-5-methyl-isoxazol-4-ylmethoxy]-nicotinic acid methyl ester

Sources & evidence

ORD record
ord-ccf20c37e0754cae895ba6b36d07d446
Source dataset
Test data from https://doi.org/10.1039/C8SC04228D

Reaction notes

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