Tetrahydrofuran → 4-(4-Bromophenyl)-4-(4-chlorophenyl)-1-methylpiperidine

HRID 806339Notes

Reaction equation

HRID 806339 reaction equation
[Al+3:27].[CH2:1]([O:2][C:4](=[O:3])[N:6]1[CH2:7][CH2:8][C:9]([c:12]2[cH:13][cH:14][c:15]([Cl:18])[cH:16][cH:17]2)([c:19]2[cH:20][cH:21][c:22]([Br:25])[cH:23][cH:24]2)[CH2:10][CH2:11]1)[CH3:5].[H-:26].[H-:29].[H-:30].[H-:31].[Li+:28].[O:32]1[CH2:33][CH2:34][CH2:35][CH2:36]1>>[CH3:4][N:6]1[CH2:7][CH2:8][C:9]([c:12]2[cH:13][cH:14][c:15]([Cl:18])[cH:16][cH:17]2)([c:19]2[cH:20][cH:21][c:22]([Br:25])[cH:23][cH:24]2)[CH2:10][CH2:11]1

Participants

6

Reactant 5

HCID 8028TetrahydrofuranHCID 28486Lithium ionHCID 104727Aluminum CationHCID 166653Hydride4×HCID 59331961HCID 59331961, compound

Product 1

HCID 576913994-(4-Bromophenyl)-4-(4-chlorophenyl)-1-methylpiperidine

Sources & evidence

ORD record
ord-bf8796b437984fa1ba7c6727942eeaaf
Source dataset
Test data from https://doi.org/10.1039/C8SC04228D

Reaction notes

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