Dimethylformamide → Methyl 2-{4-[(tert-butoxycarbonyl)amino]piperidin-1-yl}-1,3-thiazole-5-carboxylate

HRID 807217Notes

Reaction equation

HRID 807217 reaction equation
[Br:15][c:16]1[s:17][c:18]([C:21](=[O:22])[O:23][CH3:24])[cH:19][n:20]1.[CH:25]([N:26]([CH:27]([CH3:28])[CH3:29])[CH2:30][CH3:31])([CH3:32])[CH3:33].[NH:1]1[CH2:2][CH2:3][CH:4]([NH:7][C:8]([O:9][C:10]([CH3:11])([CH3:12])[CH3:13])=[O:14])[CH2:5][CH2:6]1.[O:34]=[CH:35][N:36]([CH3:37])[CH3:38]>>[N:1]1([c:16]2[s:17][c:18]([C:21](=[O:22])[O:23][CH3:24])[cH:19][n:20]2)[CH2:2][CH2:3][CH:4]([NH:7][C:8]([O:9][C:10]([CH3:11])([CH3:12])[CH3:13])=[O:14])[CH2:5][CH2:6]1

Participants

5

Reactant 4

HCID 6228DimethylformamideHCID 81531DiisopropylethylamineHCID 7238334-(N-Boc-amino)piperidineHCID 2773502Methyl 2-bromothiazole-5-carboxylate

Product 1

HCID 59679281Methyl 2-{4-[(tert-butoxycarbonyl)amino]piperidin-1-yl}-1,3-thiazole-5-carboxylate

Sources & evidence

ORD record
ord-521e7bbe3a6d4d9186f37981583df08f
Source dataset
Test data from https://doi.org/10.1039/C8SC04228D

Reaction notes

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