Acetate → Tert-butyl 4-[2-chloro-4-(tetrahydropyran-2-yloxy)phenyl]piperazine-1-carboxylate
Reaction equation
[Br:14][c:15]1[c:16]([Cl:28])[cH:17][c:18]([O:19][CH:20]2[O:21][CH2:22][CH2:23][CH2:24][CH2:25]2)[cH:26][cH:27]1.[C:88]([O-:89])(=[O:90])[CH3:91].[C:93]([O-:94])(=[O:95])[CH3:96].[CH3:75][C:76]([CH3:77])([O-:78])[CH3:79].[CH3:81][c:82]1[cH:83][cH:84][cH:85][cH:86][cH:87]1.[CH3:98][CH2:99][O:100][C:101](=[O:102])[CH3:103].[N:1]1([C:7](=[O:8])[O:9][C:10]([CH3:11])([CH3:12])[CH3:13])[CH2:2][CH2:3][NH:4][CH2:5][CH2:6]1.[Na+:80].[OH2:97].[Pd+2:92].[cH:29]1[cH:30][cH:31][c:32]([P:33]([c:34]2[cH:35][cH:36][c:37]3[c:38]([cH:39][cH:40][cH:41][cH:42]3)[c:43]2-[c:44]2[c:45]3[c:46]([cH:47][cH:48][cH:49][cH:50]3)[cH:51][cH:52][c:53]2[P:54]([c:55]2[cH:56][cH:57][cH:58][cH:59][cH:60]2)[c:61]2[cH:62][cH:63][cH:64][cH:65][cH:66]2)[c:67]2[cH:68][cH:69][cH:70][cH:71][cH:72]2)[cH:73][cH:74]1>>[N:1]1([C:7](=[O:8])[O:9][C:10]([CH3:11])([CH3:12])[CH3:13])[CH2:2][CH2:3][N:4]([c:15]2[c:16]([Cl:28])[cH:17][c:18]([O:19][CH:20]3[O:21][CH2:22][CH2:23][CH2:24][CH2:25]3)[cH:26][cH:27]2)[CH2:5][CH2:6]1Participants
11
Reactant 10
HCID 175Acetate2×
HCID 923Sodium ion
HCID 962Water
HCID 1140Toluene
HCID 8857Ethyl Acetate
HCID 105144Allyl(1,3-bis(2,6-diisopropylphenyl)imidazol-2-ylidene)chloropalladium(II)
HCID 143452tert-Butyl piperazine-1-carboxylate
HCID 634876Binap, (A+-)-
HCID 45749132-Methylpropan-2-olate
HCID 230814412-(4-Bromo-3-chlorophenoxy)tetrahydropyranProduct 1
Sources & evidence
- ORD record
- ord-ca70d127d0524c9faff399e7fd7961df
- Source dataset
- Test data from https://doi.org/10.1039/C8SC04228D
Reaction notes
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