Triphenylphosphine → 1-Bromo-4-chloro-2-(3,3,3-triethoxyprop-1-ynyl)benzene

HRID 807904Notes

Reaction equation

HRID 807904 reaction equation
[Br:1][c:2]1[c:3]([I:9])[cH:4][c:5]([Cl:8])[cH:6][cH:7]1.[CH2:10]([CH3:11])[O:12][C:13]([C:14]#[CH:15])([O:16][CH2:17][CH3:18])[O:19][CH2:20][CH3:21].[Cu:22][I:23].[Pd:24]([Cl:25])[Cl:26].[c:27]1([P:28]([c:29]2[cH:30][cH:31][cH:32][cH:33][cH:34]2)[c:35]2[cH:36][cH:37][cH:38][cH:39][cH:40]2)[cH:41][cH:42][cH:43][cH:44][cH:45]1.[c:46]1([P:47]([c:48]2[cH:49][cH:50][cH:51][cH:52][cH:53]2)[c:54]2[cH:55][cH:56][cH:57][cH:58][cH:59]2)[cH:60][cH:61][cH:62][cH:63][cH:64]1>>[Br:1][c:2]1[c:3]([C:15]#[C:14][C:13]([O:12][CH2:10][CH3:11])([O:16][CH2:17][CH3:18])[O:19][CH2:20][CH3:21])[cH:4][c:5]([Cl:8])[cH:6][cH:7]1

Participants

6

Reactant 5

HCID 11776Triphenylphosphine2×HCID 24290Palladium ChlorideHCID 24350Copper(1+) iodide; Copper(I) iodide; Cuprous iodide; Cuprous iodide (CuI)HCID 109209723,3,3-Triethoxyprop-1-yneHCID 510000721-Bromo-4-chloro-2-iodobenzene

Product 1

HCID 670999201-Bromo-4-chloro-2-(3,3,3-triethoxyprop-1-ynyl)benzene

Sources & evidence

ORD record
ord-adb466468c7b439ebf8e07beee4a167e
Source dataset
Test data from https://doi.org/10.1039/C8SC04228D

Reaction notes

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