N-methyl-2-pyrrolidone → N-(5-methylpyrazin-2-yl)-3-[(1-oxo-3,4-dihydro-2H-isoquinolin-6-yl)oxy]-5-(oxolan-3-yloxy)benzamide
Reaction equation
[Br:30][c:31]1[cH:32][c:33]2[c:38]([cH:39][cH:40]1)[C:37](=[O:41])[NH:36][CH2:35][CH2:34]2.[C:1](=[O:2])([O-:3])[O-:4].[CH3:42][C:43]([CH3:44])([C:45](=[O:46])[CH2:47][C:48](=[O:49])[C:50]([CH3:51])([CH3:52])[CH3:53])[CH3:54].[CH3:55][N:56]1[CH2:57][CH2:58][CH2:59][C:60]1=[O:61].[Cs+:5].[Cs+:6].[Cu:62][I:63].[OH:7][c:8]1[cH:9][c:10]([C:11](=[O:12])[NH:13][c:14]2[n:15][cH:16][c:17]([CH3:20])[n:18][cH:19]2)[cH:21][c:22]([O:24][CH:25]2[CH2:26][O:27][CH2:28][CH2:29]2)[cH:23]1>>[O:7]([c:8]1[cH:9][c:10]([C:11](=[O:12])[NH:13][c:14]2[n:15][cH:16][c:17]([CH3:20])[n:18][cH:19]2)[cH:21][c:22]([O:24][CH:25]2[CH2:26][O:27][CH2:28][CH2:29]2)[cH:23]1)[c:31]1[cH:32][c:33]2[c:38]([cH:39][cH:40]1)[C:37](=[O:41])[NH:36][CH2:35][CH2:34]2Participants
8
Reactant 7
HCID 13387N-methyl-2-pyrrolidone
HCID 19660Carbonate Ion
HCID 24350Copper(1+) iodide; Copper(I) iodide; Cuprous iodide; Cuprous iodide (CuI)
HCID 707002,2,6,6-Tetramethyl-3,5-heptanedione
HCID 104967Cesium cation2×
HCID 218654506-Bromo-3,4-dihydro-2H-isoquinolin-1-one
HCID 178430648HCID 178430648, compoundProduct 1
Sources & evidence
- ORD record
- ord-4c82b3f68f294d1ca18683e4cacdf988
- Source dataset
- Test data from https://doi.org/10.1039/C8SC04228D
Reaction notes
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