Hydrogen Bromide → 2-methyl-3-[2-[4-[[1-(2-pyrazinylmethyl)-1H-benzimidazol-2-yl]amino]-1-piperidinyl]ethyl]-4H-pyrido[1,2-a]pyrimidin-4-one

HRID 808550Notes

Reaction equation

HRID 808550 reaction equation
[BrH:16].[BrH:17].[BrH:18].[CH3:51][N:52]([CH3:53])[C:54](=[O:55])[CH3:56].[Cl:1][CH2:2][CH2:3][c:4]1[c:5]([CH3:15])[n:6][c:7]2[n:8]([c:9]1=[O:10])[cH:11][cH:12][cH:13][cH:14]2.[I-:49].[K+:48].[NH:19]1[CH2:20][CH2:21][CH:22]([NH:25][c:26]2[n:27][c:28]3[c:29]([n:30]2[CH2:31][c:32]2[n:33][cH:34][cH:35][n:36][cH:37]2)[cH:38][cH:39][cH:40][cH:41]3)[CH2:23][CH2:24]1.[Na+:42].[Na+:43].[O-:44][C:45](=[O:46])[O-:47].[OH2:50]>>[CH2:2]([CH2:3][c:4]1[c:5]([CH3:15])[n:6][c:7]2[n:8]([c:9]1=[O:10])[cH:11][cH:12][cH:13][cH:14]2)[N:19]1[CH2:20][CH2:21][CH:22]([NH:25][c:26]2[n:27][c:28]3[c:29]([n:30]2[CH2:31][c:32]2[n:33][cH:34][cH:35][n:36][cH:37]2)[cH:38][cH:39][cH:40][cH:41]3)[CH2:23][CH2:24]1

Participants

10

Reactant 9

HCID 260Hydrogen Bromide3×HCID 813Potassium CationHCID 923Sodium ion2×HCID 962WaterHCID 19660Carbonate IonHCID 30165Iodide IonHCID 31374DimethylacetamideHCID 8178663-(2-Chloroethyl)-2-methyl-4H-pyrido[1,2-a]pyrimidin-4-oneHCID 19890730N-piperidin-4-yl-1-(pyrazin-2-ylmethyl)benzimidazol-2-amine

Product 1

HCID 139832072-methyl-3-[2-[4-[[1-(2-pyrazinylmethyl)-1H-benzimidazol-2-yl]amino]-1-piperidinyl]ethyl]-4H-pyrido[1,2-a]pyrimidin-4-one

Sources & evidence

ORD record
ord-fe54941bffc94b09a96229a78f926a23
Source dataset
Test data from https://doi.org/10.1039/C8SC04228D

Reaction notes

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