Hydrochloric Acid → 4-Methoxy-3,3-dimethyl-1,3-dihydro-indol-2-one

Temperature

-78 °C

A solution of 4-methoxy-3-methyl-1,3-dihydro-indol-2-one (41.73 g, 235.5 mmol) and tetrahydrofuran (1000 mL) is cooled to −78° C. Potassium bis(trimethylsilyl)amide (989.0 mL, 494.3 mmol, 0.5 M in toluene) is added over 45 minutes so as to maintain the reaction temperature between −71° C. and −66° C. Iodomethane (36.71 g, 258.7 mmol) is added over 15 minutes between −75° C. and −70° C. The mixture is stirred at −78° C. for 1 hour then −60° C. for 30 minutes. Methanol (25 mL) is added at −60° C. Aqueous, hydrochloric acid (1N, 420 mL) is added rapidly allowing the temperature to rise to −7° C. The solution is transferred to a separatory funnel with aqueous hydrochloric acid (1N, 420 mL) and toluene (50 mL). The organic layer is extracted with a saturated sodium bicarbonate solution (250 mL), washed with a saturated sodium chloride solution (200 mL), dried over magnesium sulfate, and filtered. The filtrate is stirred with DARCO (25 g) for 1 hour then filtered. The filtrate is concentrated by rotary evaporation. The residue is refluxed for 1 hour in tert-butyl methyl ether (300 mL). After distilling out 100 mL of solvent, the slurry is stirred for 10 hours at 24° C. The solid is isolated by vacuum filtration rinsing twice with cold (−40° C.) tert-butyl methyl ether. After vacuum drying for 12 hours at 50° C./5 Torr, 23.9 g (58%) of 4-methoxy-3,3-dimethyl-1,3-dihydro-indol-2-one is obtained. mp 143–144° C. MS (ES+) m/z 192 (M++1).

1. temperatureto maintain the reaction temperature between −71° C. and −66° C
2. wait−60° C. for 30 minutes
3. customto rise to −7° C
4. extractionThe organic layer is extracted with a saturated sodium bicarbonate solution (250 mL)
5. washwashed with a saturated sodium chloride solution (200 mL)
6. dry with materialdried over magnesium sulfate
7. filtrationfiltered
8. stirringThe filtrate is stirred with DARCO (25 g) for 1 hour
9. filtrationthen filtered
10. concentrationThe filtrate is concentrated by rotary evaporation
11. temperatureThe residue is refluxed for 1 hour in tert-butyl methyl ether (300 mL)
12. distillationAfter distilling out 100 mL of solvent
13. stirringthe slurry is stirred for 10 hours at 24° C
14. customThe solid is isolated by vacuum filtration
15. washrinsing twice with cold (−40° C.) tert-butyl methyl ether
16. customAfter vacuum drying for 12 hours at 50° C./5 Torr

ORD record

ord-5c5f16cc6c2d49e0b89c3666d774b67a

Source dataset

uspto-grants-2006_08

DOI

10.6084/m9.figshare.5104873.v1

Patent number

US07087635B2