反应详情

NEt3 (60 mL) followed by (S)-1-(4-chloro-phenyl)-ethylamine (20.5 g) was added to a solution of 3-chloro-1-phenyl-propan-1-one (23.2 g) in tetrahydrofuran (200 mL). The resulting mixture was stirred at room temperature overnight. Then, the solution was concentrated, water (100 mL) was added to the residue, and the resulting mixture was extracted with tert-butyl methyl ether. The combined organic extracts were washed with water and brine and dried (MgSO4). The title compound was obtained after removal of the solvent.

1. concentrationThen, the solution was concentrated
2. additionwater (100 mL) was added to the residue
3. extractionthe resulting mixture was extracted with tert-butyl methyl ether
4. washThe combined organic extracts were washed with water and brine
5. dry with materialdried (MgSO4)