Dichloromethane → Methyl 3-cyclohexyl-1H-indole-6-carboxylate

HRID 809748Notes

Reaction equation

HRID 809748 reaction equation
[CH2:28]([SiH:29]([CH2:30][CH3:31])[CH2:32][CH3:33])[CH3:34].[Cl:35][CH2:36][Cl:37].[O:1]=[C:2]1[CH2:3][CH2:4][CH2:5][CH2:6][CH2:7]1.[OH:21][C:22]([C:23]([F:24])([F:25])[F:26])=[O:27].[nH:8]1[cH:9][cH:10][c:11]2[cH:12][cH:13][c:14]([C:17](=[O:18])[O:19][CH3:20])[cH:15][c:16]12>>[CH:2]1([c:10]2[cH:9][nH:8][c:16]3[c:11]2[cH:12][cH:13][c:14]([C:17](=[O:18])[O:19][CH3:20])[cH:15]3)[CH2:3][CH2:4][CH2:5][CH2:6][CH2:7]1

Participants

6

Reactant 5

HCID 6344DichloromethaneHCID 6422Trifluoroacetic acidHCID 7967CyclohexanoneHCID 12052TriethylsilaneHCID 639844Methyl indole-6-carboxylate

Product 1

HCID 11230631Methyl 3-cyclohexyl-1H-indole-6-carboxylate

Sources & evidence

ORD record
ord-37ae2310eafd40ad96c22db132fc1a22
Source dataset
Test data from https://doi.org/10.1039/C8SC04228D

Reaction notes

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