1,2-Dichloroethane → 3-Hydroxy-4-{2-[(morpholine-4-carbonyl)-amino]-3-phenylmethanesulfonyl-propionylamino}-pyrrolidine-1-carboxylic acid tert-butyl ester

HRID 809832Notes

Reaction equation

HRID 809832 reaction equation
[C:25]([CH3:26])([CH3:27])([CH3:28])[O:29][C:30](=[O:31])[N:32]1[CH2:33][CH:34]([NH2:38])[CH:35]([OH:37])[CH2:36]1.[CH2:39]([Cl:40])[CH2:41][Cl:42].[CH3:53][N:54]1[CH2:55][CH2:56][O:57][CH2:58][CH2:59]1.[Cl:60][CH2:61][Cl:62].[O:1]1[CH2:2][CH2:3][N:4]([C:7](=[O:8])[NH:9][CH:10]([C:11](=[O:12])[OH:13])[CH2:14][S:15](=[O:16])(=[O:17])[CH2:18][c:19]2[cH:20][cH:21][cH:22][cH:23][cH:24]2)[CH2:5][CH2:6]1.[OH:43][n:44]1[c:45]2[c:46]([cH:47][cH:48][cH:49][cH:50]2)[n:51][n:52]1>>[O:1]1[CH2:2][CH2:3][N:4]([C:7](=[O:8])[NH:9][CH:10]([C:11](=[O:13])[NH:38][CH:34]2[CH2:33][N:32]([C:30]([O:29][C:25]([CH3:26])([CH3:27])[CH3:28])=[O:31])[CH2:36][CH:35]2[OH:37])[CH2:14][S:15](=[O:16])(=[O:17])[CH2:18][c:19]2[cH:20][cH:21][cH:22][cH:23][cH:24]2)[CH2:5][CH2:6]1

Participants

7

Reactant 6

HCID 111,2-DichloroethaneHCID 6344DichloromethaneHCID 79724-MethylmorpholineHCID 757711-HydroxybenzotriazoleHCID 11229445tert-Butyl 3-amino-4-hydroxypyrrolidine-1-carboxylateHCID 112797342-[(Morpholine-4-carbonyl)-amino]-3-phenylmethanesulfonyl-propionic acid

Product 1

HCID 694401533-Hydroxy-4-{2-[(morpholine-4-carbonyl)-amino]-3-phenylmethanesulfonyl-propionylamino}-pyrrolidine-1-carboxylic acid tert-butyl ester

Sources & evidence

ORD record
ord-c1193dbecd484eaa96bf26a88db776eb
Source dataset
Test data from https://doi.org/10.1039/C8SC04228D

Reaction notes

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