Dimethylformamide → (1,4-Dioxa-8-aza-spiro[4.5]dec-8-yl)-[5-(4-isopropyl-piperazine-1-carbonyl)-1H-indol-2-yl]-methanone
Reaction equation
[B-:56]([F:57])([F:58])([F:59])[F:60].[CH3:97][N:98]([CH3:99])[CH:100]=[O:101].[CH:1]([CH3:2])([CH3:3])[N:4]1[CH2:5][CH2:6][N:7]([C:10](=[O:11])[c:12]2[cH:13][c:14]3[cH:15][c:16]([C:21](=[O:22])[OH:23])[nH:17][c:18]3[cH:19][cH:20]2)[CH2:8][CH2:9]1.[CH:24]1([N:25]2[CH2:26][CH2:27][N:28]([C:29]([c:30]3[cH:31][c:32]4[c:33]([cH:34][cH:35]3)[nH:36][c:37]([C:38]([N:39]3[CH2:40][CH2:41][S:42](=[O:43])(=[O:44])[CH2:45][CH2:46]3)=[O:47])[cH:48]4)=[O:49])[CH2:50][CH2:51]2)[CH2:52][CH2:53][CH2:54][CH2:55]1.[CH:88]([N:89]([CH2:90][CH3:91])[CH:92]([CH3:93])[CH3:94])([CH3:95])[CH3:96].[O:78]1[CH2:79][CH2:80][O:81][C:82]12[CH2:83][CH2:84][NH:85][CH2:86][CH2:87]2.[n:61]1([O:62][C:63]([N:64]([CH3:65])[CH3:66])=[N+:67]([CH3:68])[CH3:69])[c:70]2[cH:71][cH:72][cH:73][cH:74][c:75]2[n:76][n:77]1>>[CH:1]([CH3:2])([CH3:3])[N:4]1[CH2:5][CH2:6][N:7]([C:10](=[O:11])[c:12]2[cH:13][c:14]3[cH:15][c:16]([C:21](=[O:23])[N:85]4[CH2:84][CH2:83][C:82]5([O:78][CH2:79][CH2:80][O:81]5)[CH2:87][CH2:86]4)[nH:17][c:18]3[cH:19][cH:20]2)[CH2:8][CH2:9]1Participants
8
Reactant 7
HCID 6228Dimethylformamide
HCID 26255Tetrafluoroborate
HCID 674351,4-Dioxa-8-azaspiro(4.5)decane
HCID 81531Diisopropylethylamine
HCID 130500O-benzotriazol-1-yl-tetramethyluronium
HCID 685341205-(4-isopropyl-piperazine-1-carbonyl)-1H-indole-2-carboxylic acid
HCID 68680722[5-(4-Cyclopentyl-piperazine-1-carbonyl)-1H-indol-2-yl]-(1,1-dioxo-thiomorpholin-4-yl)-methanoneProduct 1
Sources & evidence
- ORD record
- ord-a045b96ee43546869e921c71e7c2dcb1
- Source dataset
- Test data from https://doi.org/10.1039/C8SC04228D
Reaction notes
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