Hydrochloric Acid → 4-(1-(5-Bromopyrimidin-2-yl)piperidin-4-yloxy)-1-(4-cyano-3-fluorophenyl)-6-oxo-1,6-dihydropyridazine-3-carbonitrile

HRID 810188Notes

Reaction equation

HRID 810188 reaction equation
[Br:36][c:37]1[cH:38][n:39][c:40]([Cl:43])[n:41][cH:42]1.[C:44](#[N:45])[c:46]1[c:47]([F:68])[cH:48][c:49](-[n:52]2[n:53][c:54]([C:66]#[N:67])[c:55]([O:59][CH:60]3[CH2:61][CH2:62][NH:63][CH2:64][CH2:65]3)[cH:56][c:57]2=[O:58])[cH:50][cH:51]1.[Cl:11][c:12]1[cH:13][c:14](-[n:15]2[c:16](=[O:17])[cH:18][c:19]([O:20][CH:21]3[CH2:22][CH2:23][NH:24][CH2:25][CH2:26]3)[c:27]([C:28]#[N:29])[n:30]2)[cH:31][cH:32][c:33]1[Cl:34].[Cl:1][c:2]1[n:3][cH:4][c:5]([CH:6]2[CH2:7][CH2:8]2)[cH:9][n:10]1.[ClH:35]>>[Br:36][c:37]1[cH:38][n:39][c:40]([N:63]2[CH2:62][CH2:61][CH:60]([O:59][c:55]3[c:54]([C:66]#[N:67])[n:53][n:52](-[c:49]4[cH:48][c:47]([F:68])[c:46]([C:44]#[N:45])[cH:51][cH:50]4)[c:57](=[O:58])[cH:56]3)[CH2:65][CH2:64]2)[n:41][cH:42]1

Participants

6

Reactant 5

HCID 313Hydrochloric AcidHCID 6066655-Bromo-2-chloropyrimidineHCID 468640872-Chloro-5-cyclopropylpyrimidineHCID 674439611-(4-Cyano-3-fluorophenyl)-6-oxo-4-piperidin-4-yloxypyridazine-3-carbonitrileHCID 674455871-(3,4-Dichlorophenyl)-6-oxo-4-piperidin-4-yloxypyridazine-3-carbonitrile

Product 1

HCID 446210894-(1-(5-Bromopyrimidin-2-yl)piperidin-4-yloxy)-1-(4-cyano-3-fluorophenyl)-6-oxo-1,6-dihydropyridazine-3-carbonitrile

Sources & evidence

ORD record
ord-f5e0af7ceff04bb7aa85f60fc1743434
Source dataset
Test data from https://doi.org/10.1039/C8SC04228D

Reaction notes

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