Felbinac → 2-Biphenyl-4-yl-3-cyclopentylpropionic acid

HRID 810334Notes

Reaction equation

HRID 810334 reaction equation
[CH2:8]([Li:9])[CH2:10][CH2:11][CH3:12].[CH3:41][N:42]1[CH2:43][CH2:44][CH2:45][N:46]([CH3:47])[C:48]1=[O:49].[CH:1]([NH:2][CH:3]([CH3:4])[CH3:5])([CH3:6])[CH3:7].[I:29][CH2:30][CH:31]1[CH2:32][CH2:33][CH2:34][CH2:35]1.[O:36]1[CH2:37][CH2:38][CH2:39][CH2:40]1.[c:13]1(-[c:23]2[cH:24][cH:25][cH:26][cH:27][cH:28]2)[cH:14][cH:15][c:16]([CH2:19][C:20](=[O:21])[OH:22])[cH:17][cH:18]1>>[c:13]1(-[c:23]2[cH:24][cH:25][cH:26][cH:27][cH:28]2)[cH:14][cH:15][c:16]([CH:19]([C:20](=[O:21])[OH:22])[CH2:30][CH:31]2[CH2:32][CH2:33][CH2:34][CH2:35]2)[cH:17][cH:18]1

Participants

7

Reactant 6

HCID 3332FelbinacHCID 7912DiisopropylamineHCID 8028TetrahydrofuranHCID 816462(1H)-Pyrimidinone, tetrahydro-1,3-dimethyl-HCID 2762531(Iodomethyl)cyclopentaneHCID 178418339Butyllithium

Product 1

HCID 224679232-Biphenyl-4-yl-3-cyclopentylpropionic acid

Sources & evidence

ORD record
ord-bc209ae99f9e4d4a8f97d9f8600c75d8
Source dataset
Test data from https://doi.org/10.1039/C8SC04228D

Reaction notes

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