Methane → Tert-butyl 4-[4-(2-amino-5-chlorophenoxy)phenyl]piperazine-1-carboxylate

HRID 810887Notes

Reaction equation

HRID 810887 reaction equation
[C:32].[CH3:33][CH2:34][O:35][C:36](=[O:37])[CH3:38].[Cl:1][c:2]1[cH:3][cH:4][c:5]([N+:28]([O-:29])=[O:30])[c:6]([O:7][c:8]2[cH:9][cH:10][c:11]([N:14]3[CH2:15][CH2:16][N:17]([C:20](=[O:21])[O:22][C:23]([CH3:24])([CH3:25])[CH3:26])[CH2:18][CH2:19]3)[cH:12][cH:13]2)[cH:27]1.[Pd:31]>>[Cl:1][c:2]1[cH:3][cH:4][c:5]([NH2:28])[c:6]([O:7][c:8]2[cH:9][cH:10][c:11]([N:14]3[CH2:15][CH2:16][N:17]([C:20](=[O:21])[O:22][C:23]([CH3:24])([CH3:25])[CH3:26])[CH2:18][CH2:19]3)[cH:12][cH:13]2)[cH:27]1

Participants

5

Reactant 4

HCID 297MethaneHCID 8857Ethyl AcetateHCID 23938PalladiumHCID 17815432Tert-butyl 4-[4-(5-chloro-2-nitrophenoxy)phenyl]piperazine-1-carboxylate

Product 1

HCID 17815784Tert-butyl 4-[4-(2-amino-5-chlorophenoxy)phenyl]piperazine-1-carboxylate

Sources & evidence

ORD record
ord-9992ed8e7d954904a7df7f8835b0808e
Source dataset
Test data from https://doi.org/10.1039/C8SC04228D

Reaction notes

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