Ammonium → Tert-butyl 6-(4-amino-4-methylpiperidin-1-yl)pyridine-3-carboxylate

HRID 810889Notes

Reaction equation

HRID 810889 reaction equation
[C:1]([CH3:2])([CH3:3])([CH3:4])[O:5][C:6](=[O:7])[c:8]1[cH:9][cH:10][c:11]([N:14]2[CH2:15][CH2:16][C:17]([CH3:20])([NH:21][C:22]([O:23][CH2:24][c:25]3[cH:26][cH:27][cH:28][cH:29][cH:30]3)=[O:31])[CH2:18][CH2:19]2)[n:12][cH:13]1.[CH3:40][OH:41].[CH3:42][CH2:43][O:44][C:45](=[O:46])[CH3:47].[CH:32]([O-:33])=[O:34].[CH:36]([OH:37])([CH3:38])[CH3:39].[NH4+:35]>>[C:1]([CH3:2])([CH3:3])([CH3:4])[O:5][C:6](=[O:7])[c:8]1[cH:9][cH:10][c:11]([N:14]2[CH2:15][CH2:16][C:17]([CH3:20])([NH2:21])[CH2:18][CH2:19]2)[n:12][cH:13]1

Participants

7

Reactant 6

HCID 223AmmoniumHCID 283FormateHCID 887MethanolHCID 3776IsopropanolHCID 8857Ethyl AcetateHCID 667571374-benzyloxycarbonylamino-4methyl-3,4,5,6-tetrahydro-2H-(1,2')bipyridinyl-5'-carboxylic acid tert-butyl ester

Product 1

HCID 66756953Tert-butyl 6-(4-amino-4-methylpiperidin-1-yl)pyridine-3-carboxylate

Sources & evidence

ORD record
ord-f87121f68ec54c7d944232f04a2edfeb
Source dataset
Test data from https://doi.org/10.1039/C8SC04228D

Reaction notes

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