Diglyme → 3-(4-Methyl-1H-imidazol-1-yl)-5-(trifluoromethyl)aniline

HRID 810905Notes

Reaction equation

HRID 810905 reaction equation
[Br:9][c:10]1[cH:11][c:12]([NH2:20])[cH:13][c:14]([C:16]([F:17])([F:18])[F:19])[cH:15]1.[C:1]1([NH2:2])([NH2:3])[CH2:4][CH2:5][CH2:6][CH2:7][CH2:8]1.[C:27](=[O:28])([O-:29])[O-:30].[CH3:21][c:22]1[n:23][cH:24][nH:25][cH:26]1.[CH3:35][O:36][CH2:37][CH2:38][O:39][CH2:40][CH2:41][O:42][CH3:43].[Cs+:31].[Cs+:32].[Cu:33][I:34]>>[c:10]1(-[n:25]2[cH:24][n:23][c:22]([CH3:21])[cH:26]2)[cH:11][c:12]([NH2:20])[cH:13][c:14]([C:16]([F:17])([F:18])[F:19])[cH:15]1

Participants

8

Reactant 7

HCID 8150DiglymeHCID 19660Carbonate IonHCID 24350Copper(1+) iodide; Copper(I) iodide; Cuprous iodide; Cuprous iodide (CuI)HCID 104967Cesium cation2×HCID 27358803-Bromo-5-(trifluoromethyl)anilineHCID 17842493Cyclohexane-1,1-diamineHCID 178418800HCID 178418800, compound

Product 1

HCID 120028253-(4-Methyl-1H-imidazol-1-yl)-5-(trifluoromethyl)aniline

Sources & evidence

ORD record
ord-fa947f4577194e889e06a101af881131
Source dataset
Test data from https://doi.org/10.1039/C8SC04228D

Reaction notes

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