3-Pyridinemethanamine → 4-[4-(4-Fluoro-phenyl)-piperidin-1-yl]-2-[(pyridin-3-ylmethyl)-amino]-6-(2,2,2-trifluoro-ethoxy)-pyrimidine-5-carbonitrile

HRID 811055Notes

Reaction equation

[Cl:30][c:31]1[cH:32][cH:33][cH:34][c:35]([C:36]([O:37][OH:38])=[O:39])[cH:40]1.[F:1][c:2]1[cH:3][cH:4][c:5]([CH:8]2[CH2:9][CH2:10][N:11]([c:14]3[n:15][c:16]([S:28][CH3:29])[n:17][c:18]([O:22][CH2:23][C:24]([F:25])([F:26])[F:27])[c:19]3[C:20]#[N:21])[CH2:12][CH2:13]2)[cH:6][cH:7]1.[F:41][c:42]1[cH:43][cH:44][c:45]([CH:46]2[CH2:47][CH2:48][N:49]([c:50]3[c:51]([C:52]#[N:53])[c:54]([O:55][CH2:56][C:57]([F:58])([F:59])[F:60])[n:61][c:62]([S:63]([CH3:64])(=[O:65])=[O:66])[n:67]3)[CH2:68][CH2:69]2)[cH:70][cH:71]1.[O:80]1[CH2:81][CH2:82][O:83][CH2:84][CH2:85]1.[cH:72]1[c:73]([CH2:78][NH2:79])[cH:74][cH:75][cH:76][n:77]1>>[F:1][c:2]1[cH:3][cH:4][c:5]([CH:8]2[CH2:9][CH2:10][N:11]([c:14]3[n:15][c:16]([NH:79][CH2:78][c:73]4[cH:72][n:77][cH:76][cH:75][cH:74]4)[n:17][c:18]([O:22][CH2:23][C:24]([F:25])([F:26])[F:27])[c:19]3[C:20]#[N:21])[CH2:12][CH2:13]2)[cH:6][cH:7]1