Dichloromethane → 7-Dimethylamino-8-(2-fluoro-phenyl)-4-(3-pyridin-4-yl-phenyl)-1,3-dihydro-benzo[b][1,4]diazepin-2-one

HRID 811475Notes

Reaction equation

[C:1]([O:2][C:3](=[O:4])[NH:7][c:8]1[cH:9][c:10]([N:39]([CH3:40])[CH3:41])[c:11](-[c:32]2[c:33]([F:38])[cH:34][cH:35][cH:36][cH:37]2)[cH:12][c:13]1[NH:14][C:15]([CH2:16][C:17](=[O:5])[c:18]1[cH:19][c:20](-[c:24]2[cH:25][cH:26][n:27][cH:28][cH:29]2)[cH:21][cH:22][cH:23]1)=[O:31])([CH3:6])([CH3:30])[CH3:42].[Cl:50][CH2:51][Cl:52].[F:43][C:44]([F:45])([F:46])[C:47]([OH:48])=[O:49]>>[N:7]1=[C:17]([c:18]2[cH:19][c:20](-[c:24]3[cH:25][cH:26][n:27][cH:28][cH:29]3)[cH:21][cH:22][cH:23]2)[CH2:16][C:15](=[O:31])[NH:14][c:13]2[c:8]1[cH:9][c:10]([N:39]([CH3:40])[CH3:41])[c:11](-[c:32]1[c:33]([F:38])[cH:34][cH:35][cH:36][cH:37]1)[cH:12]2

Participants

Reactant 3

HCID 6344Dichloromethane

HCID 6422Trifluoroacetic acid

HCID 86589252{2-Dimethylamino-2'-fluoro-5-(3-oxo-3-(3-pyridin-4-yl-phenyl)-propionylamino]-biphenyl-4-yl}-carbamic acid tert-butyl ester

Product 1

HCID 223173577-Dimethylamino-8-(2-fluoro-phenyl)-4-(3-pyridin-4-yl-phenyl)-1,3-dihydro-benzo[b][1,4]diazepin-2-one

Sources & evidence

ORD record: ord-43918eebf31c4481a0fe16eb3cdc7310
Source dataset: Test data from https://doi.org/10.1039/C8SC04228D
DOI: 10.1039/C8SC04228D

Reaction notes

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