Dimethylformamide → tert-butyl 4-((4-(2-(3-isopropylphenylamino)-1-methyl-1H-benzo[d]imidazol-5-yloxy)pyridin-2-ylcarbamoyl)methyl)piperidine-1-carboxylate
Reaction equation
[C:1]([CH3:2])([CH3:3])([CH3:4])[O:5][C:6](=[O:7])[N:8]1[CH2:9][CH2:10][CH:11]([CH2:14][C:15](=[O:16])[OH:17])[CH2:12][CH2:13]1.[CH3:75][N:76]([CH3:77])[c:78]1[cH:79][cH:80][n:81][cH:82][cH:83]1.[CH:70]([N:71]([CH3:72])[CH3:73])=[O:74].[NH2:42][c:43]1[n:44][cH:45][cH:46][c:47]([O:49][c:50]2[cH:51][c:52]3[c:53]([n:54]([CH3:67])[c:55]([NH:57][c:58]4[cH:59][c:60]([CH:64]([CH3:65])[CH3:66])[cH:61][cH:62][cH:63]4)[n:56]3)[cH:68][cH:69]2)[cH:48]1.[P-:18]([F:19])([F:20])([F:21])([F:22])([F:23])[F:24].[n:25]1([O:26][C:27]([N:28]([CH3:29])[CH3:30])=[N+:31]([CH3:32])[CH3:33])[c:34]2[n:35][cH:36][cH:37][cH:38][c:39]2[n:40][n:41]1>>[C:1]([CH3:2])([CH3:3])([CH3:4])[O:5][C:6](=[O:7])[N:8]1[CH2:9][CH2:10][CH:11]([CH2:14][C:15](=[O:17])[NH:42][c:43]2[n:44][cH:45][cH:46][c:47]([O:49][c:50]3[cH:51][c:52]4[c:53]([n:54]([CH3:67])[c:55]([NH:57][c:58]5[cH:59][c:60]([CH:64]([CH3:65])[CH3:66])[cH:61][cH:62][cH:63]5)[n:56]4)[cH:68][cH:69]3)[cH:48]2)[CH2:12][CH2:13]1Participants
7
Reactant 6
HCID 6228Dimethylformamide
HCID 9886Hexafluorophosphate
HCID 142844-(Dimethylamino)pyridine
HCID 1512539[1-(tert-Butoxycarbonyl)piperidin-4-yl]acetic acid
HCID 4641409(Dimethylamino)-N,N-dimethyl(3H-(1,2,3)triazolo(4,5-b)pyridin-3-yloxy)methaniminium
HCID 690065885-(2-aminopyridin-4-yloxy)-N-(3-isopropylphenyl)-1-methyl-1H-benzo[d]imidazol-2-amineProduct 1
Sources & evidence
- ORD record
- ord-42506e5e5617426481c3a84fabc2aa5b
- Source dataset
- Test data from https://doi.org/10.1039/C8SC04228D
Reaction notes
Loading…