Acetate → Tert-butyl 4-[2-(4,4-diethylcyclohexyl)-4-(3-methoxypiperidin-1-yl)phenyl]piperazine-1-carboxylate
Reaction equation
[B-:46]([F:47])([F:48])([F:49])[F:50].[C:1]([CH3:2])([CH3:3])([CH3:4])[O:5][C:6](=[O:7])[N:8]1[CH2:9][CH2:10][N:11]([c:14]2[c:15]([CH:21]3[CH2:22][CH2:23][C:24]([CH2:27][CH3:28])([CH2:29][CH3:30])[CH2:25][CH2:26]3)[cH:16][c:17]([Br:20])[cH:18][cH:19]2)[CH2:12][CH2:13]1.[C:51]([PH+:52]([C:53]([CH3:54])([CH3:55])[CH3:56])[C:57]([CH3:58])([CH3:59])[CH3:60])([CH3:61])([CH3:62])[CH3:63].[CH3:32][O:33][CH:34]1[CH2:35][NH:36][CH2:37][CH2:38][CH2:39]1.[CH3:40][C:41]([CH3:42])([O-:43])[CH3:44].[ClH:31].[Na+:45].[O-:65][C:66]([CH3:67])=[O:68].[O-:69][C:70]([CH3:71])=[O:72].[Pd+2:64].[c:73]1([CH3:74])[c:75]([CH3:76])[cH:77][cH:78][cH:79][cH:80]1>>[C:1]([CH3:2])([CH3:3])([CH3:4])[O:5][C:6](=[O:7])[N:8]1[CH2:9][CH2:10][N:11]([c:14]2[c:15]([CH:21]3[CH2:22][CH2:23][C:24]([CH2:27][CH3:28])([CH2:29][CH3:30])[CH2:25][CH2:26]3)[cH:16][c:17]([N:36]3[CH2:35][CH:34]([O:33][CH3:32])[CH2:39][CH2:38][CH2:37]3)[cH:18][cH:19]2)[CH2:12][CH2:13]1Participants
11
Reactant 10
HCID 175Acetate2×
HCID 313Hydrochloric Acid
HCID 923Sodium ion
HCID 7237O-Xylene
HCID 26255Tetrafluoroborate
HCID 105144Allyl(1,3-bis(2,6-diisopropylphenyl)imidazol-2-ylidene)chloropalladium(II)
HCID 4060964Tri-t-butylphosphonium
HCID 43417443-Methoxypiperidine
HCID 45749132-Methylpropan-2-olate
HCID 597694214-[4-Bromo-2-(4,4-diethylcyclohexyl)phenyl]piperazine-1-carboxylic acid t-butyl esterProduct 1
Sources & evidence
- ORD record
- ord-a15546ddfa3c4f32b950190b067cc13f
- Source dataset
- Test data from https://doi.org/10.1039/C8SC04228D
Reaction notes
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