Triethylamine → 4-(4,6,7-Trimethoxy-quinazolin-2-ylamino)-piperidine-1-carboxylic acid tert-butyl ester

HRID 812176Notes

Reaction equation

HRID 812176 reaction equation
[C:18]([CH3:19])([CH3:20])([CH3:21])[O:22][C:23](=[O:24])[N:25]1[CH2:26][CH2:27][CH:28]([NH2:31])[CH2:29][CH2:30]1.[CH3:32][CH2:33][N:34]([CH2:35][CH3:36])[CH2:37][CH3:38].[CH3:39][N:40]1[CH2:41][CH2:42][CH2:43][C:44]1=[O:45].[Cl:1][c:2]1[n:3][c:4]2[cH:5][c:6]([O:16][CH3:17])[c:7]([O:14][CH3:15])[cH:8][c:9]2[c:10]([O:12][CH3:13])[n:11]1>>[c:2]1([NH:31][CH:28]2[CH2:27][CH2:26][N:25]([C:23]([O:22][C:18]([CH3:19])([CH3:20])[CH3:21])=[O:24])[CH2:30][CH2:29]2)[n:3][c:4]2[cH:5][c:6]([O:16][CH3:17])[c:7]([O:14][CH3:15])[cH:8][c:9]2[c:10]([O:12][CH3:13])[n:11]1

Participants

5

Reactant 4

HCID 8471TriethylamineHCID 13387N-methyl-2-pyrrolidoneHCID 12682914-Amino-1-Boc-piperidineHCID 221203552-Chloro-4,6,7-trimethoxyquinazoline

Product 1

HCID 687835484-(4,6,7-Trimethoxy-quinazolin-2-ylamino)-piperidine-1-carboxylic acid tert-butyl ester

Sources & evidence

ORD record
ord-5a8b35aad5aa4ba594c74525fcc4a84e
Source dataset
Test data from https://doi.org/10.1039/C8SC04228D

Reaction notes

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