Water → 3-Methyl-5-[4-(2,2,2-trifluoro-1-hydroxy-ethyl)-pyridin-3-yl]-3H-benzooxazol-2-one

HRID 812198Notes

Reaction equation

HRID 812198 reaction equation
[CH2:2]([N+:3]([CH2:4][CH2:5][CH2:6][CH3:7])([CH2:8][CH2:9][CH2:10][CH3:11])[CH2:12][CH2:13][CH2:14][CH3:15])[CH2:16][CH2:17][CH3:18].[CH2:46]1[O:47][CH2:48][CH2:49][CH2:50]1.[CH3:19][n:20]1[c:21](=[O:37])[o:22][c:23]2[c:24]1[cH:25][c:26](-[c:29]1[cH:30][n:31][cH:32][cH:33][c:34]1[CH:35]=[O:36])[cH:27][cH:28]2.[CH3:51][CH2:52][O:53][C:54](=[O:55])[CH3:56].[F-:1].[F:38][C:39]([F:40])([F:41])[Si:42]([CH3:43])([CH3:44])[CH3:45].[OH2:57]>>[CH3:19][n:20]1[c:21](=[O:37])[o:22][c:23]2[c:24]1[cH:25][c:26](-[c:29]1[cH:30][n:31][cH:32][cH:33][c:34]1[CH:35]([OH:36])[C:39]([F:38])([F:40])[F:41])[cH:27][cH:28]2

Participants

8

Reactant 7

HCID 962WaterHCID 8028TetrahydrofuranHCID 8857Ethyl AcetateHCID 16028TetrabutylammoniumHCID 28179Fluoride IonHCID 552549(Trifluoromethyl)trimethylsilaneHCID 866633583-(3-Methyl-2-oxo-2,3-dihydrobenzo[d]oxazol-5-yl)isonicotinaldehyde

Product 1

HCID 667978543-Methyl-5-[4-(2,2,2-trifluoro-1-hydroxy-ethyl)-pyridin-3-yl]-3H-benzooxazol-2-one

Sources & evidence

ORD record
ord-ed7071a94885403286d940a5aaa11e3b
Source dataset
Test data from https://doi.org/10.1039/C8SC04228D

Reaction notes

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