Acetate → 7-[3-[[4-[5-(Acetamidomethyl)-2-oxo-1,3-oxazolidin-3-yl]-2-fluorophenoxy]methyl]-3-hydroxypyrrolidin-1-yl]-1-cyclopropyl-6-fluoro-4-oxoquinoline-3-carboxylic acid

HRID 812231Notes

Reaction equation

HRID 812231 reaction equation
[B+2:35].[C:27]([O-:28])(=[O:29])[CH3:30].[C:31]([O-:32])(=[O:33])[CH3:34].[CH2:55]([N:56]([CH:57]([CH3:58])[CH3:59])[CH:60]([CH3:61])[CH3:62])[CH3:63].[CH3:64][N:65]1[CH2:66][CH2:67][CH2:68][C:69]1=[O:70].[Cl:36][c:37]1[c:38]([F:54])[cH:39][c:40]2[c:41](=[O:53])[c:42]([C:50](=[O:51])[OH:52])[cH:43][n:44]([CH:47]3[CH2:48][CH2:49]3)[c:45]2[cH:46]1.[F:1][c:2]1[cH:3][c:4]([N:16]2[C:17](=[O:26])[O:18][CH:19]([CH2:21][NH:22][C:23]([CH3:24])=[O:25])[CH2:20]2)[cH:5][cH:6][c:7]1[O:8][CH2:9][C:10]1([OH:15])[CH2:11][NH:12][CH2:13][CH2:14]1>>[F:1][c:2]1[cH:3][c:4]([N:16]2[C:17](=[O:26])[O:18][CH:19]([CH2:21][NH:22][C:23]([CH3:24])=[O:25])[CH2:20]2)[cH:5][cH:6][c:7]1[O:8][CH2:9][C:10]1([OH:15])[CH2:11][N:12]([c:37]2[c:38]([F:54])[cH:39][c:40]3[c:41](=[O:53])[c:42]([C:50](=[O:51])[OH:52])[cH:43][n:44]([CH:47]4[CH2:48][CH2:49]4)[c:45]3[cH:46]2)[CH2:13][CH2:14]1

Participants

7

Reactant 6

HCID 175Acetate2×HCID 13387N-methyl-2-pyrrolidoneHCID 81531DiisopropylethylamineHCID 483180Fluoroquinolonic acidHCID 118524610N-[[3-[3-fluoro-4-[(3-hydroxypyrrolidin-3-yl)methoxy]phenyl]-2-oxo-1,3-oxazolidin-5-yl]methyl]acetamideHCID 178419125HCID 178419125, compound

Product 1

HCID 724617117-[3-[[4-[5-(Acetamidomethyl)-2-oxo-1,3-oxazolidin-3-yl]-2-fluorophenoxy]methyl]-3-hydroxypyrrolidin-1-yl]-1-cyclopropyl-6-fluoro-4-oxoquinoline-3-carboxylic acid

Sources & evidence

ORD record
ord-4620acb645e1458b80ec4a7fc8d59582
Source dataset
Test data from https://doi.org/10.1039/C8SC04228D

Reaction notes

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