Hydrochloric Acid → 3-Iodo-8-(4-methyl-piperazin-1-yl)-quinoline

HRID 812316Notes

Reaction equation

HRID 812316 reaction equation
[Br:1][c:2]1[cH:3][n:4][c:5]2[c:6]([N:12]3[CH2:13][CH2:14][N:15]([CH3:18])[CH2:16][CH2:17]3)[cH:7][cH:8][cH:9][c:10]2[cH:11]1.[CH3:21][c:22]1[cH:23][cH:24][cH:25][cH:26][cH:27]1.[CH3:29][N:30]([P:31]([N:32]([CH3:33])[CH3:34])([N:35]([CH3:36])[CH3:37])=[O:38])[CH3:39].[ClH:28].[Cu:40][I:41].[I-:20].[K+:19]>>[c:2]1([I:20])[cH:3][n:4][c:5]2[c:6]([N:12]3[CH2:13][CH2:14][N:15]([CH3:18])[CH2:16][CH2:17]3)[cH:7][cH:8][cH:9][c:10]2[cH:11]1

Participants

8

Reactant 7

HCID 313Hydrochloric AcidHCID 813Potassium CationHCID 1140TolueneHCID 12679HexamethylphosphoramideHCID 24350Copper(1+) iodide; Copper(I) iodide; Cuprous iodide; Cuprous iodide (CuI)HCID 30165Iodide IonHCID 673136243-Bromo-8-(4-methyl-piperazin-1-yl)-quinoline

Product 1

HCID 673137463-Iodo-8-(4-methyl-piperazin-1-yl)-quinoline

Sources & evidence

ORD record
ord-8a2c3930de29469ea11fe927ea2a2192
Source dataset
Test data from https://doi.org/10.1039/C8SC04228D

Reaction notes

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