Hydrochloric Acid → ethyl-2-[4-[[5-methyl-3-(trifluoromethyl)-1H-pyrazol-1-yl]acetyl]-1-piperazinyl]-4-thiazolecarboxylate
Reaction equation
[C:62](=[O:63])([O-:64])[O-:65].[CH2:1]([O:2][C:3]([c:4]1[n:5][c:6]([CH:7]2[CH2:12][CH2:13][N:14]([C:17]([CH2:18][n:19]3[n:20][c:21]([C:25]([F:26])([F:27])[F:28])[cH:22][c:23]3[CH3:24])=[O:29])[CH2:15][CH2:16]2)[s:8][cH:9]1)=[O:10])[CH3:11].[CH3:71][CH2:72][N:73]([CH2:74][CH3:75])[CH2:76][CH3:77].[Cl:68][CH2:69][Cl:70].[ClH:30].[ClH:45].[K+:66].[K+:67].[N:31]1([c:32]2[s:33][cH:34][c:35]([C:36]([OH:37])=[O:38])[n:39]2)[CH2:40][CH2:41][NH:42][CH2:43][CH2:44]1.[N:46]1([c:52]2[s:53][cH:54][c:55]([C:57](=[O:58])[O:59][CH2:60][CH3:61])[n:56]2)[CH2:47][CH2:48][NH:49][CH2:50][CH2:51]1>>[CH2:12]1[CH2:13][N:14]([C:17]([CH2:18][n:19]2[n:20][c:21]([C:25]([F:26])([F:27])[F:28])[cH:22][c:23]2[CH3:24])=[O:29])[CH2:15][CH2:16][N:46]1[c:52]1[s:53][cH:54][c:55]([C:57](=[O:58])[O:59][CH2:60][CH3:61])[n:56]1Participants
9
Reactant 8
HCID 313Hydrochloric Acid2×
HCID 813Potassium Cation2×
HCID 6344Dichloromethane
HCID 8471Triethylamine
HCID 19660Carbonate Ion
HCID 13654521Ethyl 2-piperazin-1-yl-thiazole-4-carboxylate
HCID 657211312-(Piperazin-1-yl)thiazole-4-carboxylic acid
HCID 66911511ethyl-2-[1-[[5-methyl-3-(trifluoromethyl)-1H-pyrazol-1-yl]acetyl]-4-piperidinyl]-4-thiazolecarboxylateProduct 1
Sources & evidence
- ORD record
- ord-364ae15bf41d4ee9a70c3cfb0ba97cee
- Source dataset
- Test data from https://doi.org/10.1039/C8SC04228D
Reaction notes
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