p-Bromochlorobenzene → Tert-butyl 8-(4-chlorophenyl)-8-hydroxy-5-azaspiro[2.5]octane-5-carboxylate

HRID 812985Notes

Reaction equation

[Br:1][c:2]1[cH:3][cH:4][c:5]([Cl:8])[cH:6][cH:7]1.[CH2:30]1[O:31][CH2:32][CH2:33][CH2:34]1.[CH3:9][CH2:10][CH2:11][CH2:12][Li:13].[O:14]=[C:15]1[CH2:16][CH2:17][N:18]([C:23](=[O:24])[O:25][C:26]([CH3:27])([CH3:28])[CH3:29])[CH2:19][C:20]12[CH2:21][CH2:22]2>>[c:2]1([C:15]2([OH:14])[CH2:16][CH2:17][N:18]([C:23](=[O:24])[O:25][C:26]([CH3:27])([CH3:28])[CH3:29])[CH2:19][C:20]23[CH2:21][CH2:22]3)[cH:3][cH:4][c:5]([Cl:8])[cH:6][cH:7]1