Sodium ion → 3-(3-(4-(3-Methoxy-benzyloxy)-benzyl)-isoxazol-5-yl)-pyridin-2,6-diamine

HRID 813131Notes

Reaction equation

HRID 813131 reaction equation
[CH3:29][O:30][c:31]1[cH:32][c:33]([CH2:34][Cl:35])[cH:36][cH:37][cH:38]1.[CH3:39][N:40]([CH3:41])[CH:42]=[O:43].[NH2:6][c:7]1[n:8][c:9]([NH2:26])[cH:10][cH:11][c:12]1-[c:13]1[cH:14][c:15]([CH2:18][c:19]2[cH:20][cH:21][c:22]([OH:25])[cH:23][cH:24]2)[n:16][o:17]1.[Na+:28].[O:1]1[CH2:2][CH2:3][CH2:4][CH2:5]1.[OH-:27]>>[NH2:6][c:7]1[n:8][c:9]([NH2:26])[cH:10][cH:11][c:12]1-[c:13]1[cH:14][c:15]([CH2:18][c:19]2[cH:20][cH:21][c:22]([O:25][CH2:34][c:33]3[cH:32][c:31]([O:30][CH3:29])[cH:38][cH:37][cH:36]3)[cH:23][cH:24]2)[n:16][o:17]1

Participants

7

Reactant 6

HCID 923Sodium ionHCID 961HydroxideHCID 6228DimethylformamideHCID 8028TetrahydrofuranHCID 699943-Methoxybenzyl chlorideHCID 592553274-(5-(2,6-Diamino-pyridine-3-yl)-isoxazol-3-ylmethyl)phenol

Product 1

HCID 592552303-(3-(4-(3-Methoxy-benzyloxy)-benzyl)-isoxazol-5-yl)-pyridin-2,6-diamine

Sources & evidence

ORD record
ord-d48c5ddd5cbf4d0c81e19689e17fab1c
Source dataset
Test data from https://doi.org/10.1039/C8SC04228D

Reaction notes

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