Sodium ion → (2RS,5SR)-2-(4-Fluoro-phenyl)-5-methoxymethyl-1-(toluene-4-sulfonyl)-pyrrolidine

HRID 813663Notes

Reaction equation

HRID 813663 reaction equation
[C:35]([O:36][CH2:37][CH3:38])(=[O:39])[CH3:40].[CH2:41]1[O:42][CH2:43][CH2:44][CH2:45]1.[CH3:27][I:28].[CH3:29][CH2:30][CH2:31][CH2:32][CH2:33][CH3:34].[F:1][c:2]1[cH:3][cH:4][c:5]([CH:8]2[CH2:9][CH2:10][CH:11]([CH2:23][OH:24])[N:12]2[S:13](=[O:14])(=[O:15])[c:16]2[cH:17][cH:18][c:19]([CH3:22])[cH:20][cH:21]2)[cH:6][cH:7]1.[H-:25].[Na+:26]>>[F:1][c:2]1[cH:3][cH:4][c:5]([CH:8]2[CH2:9][CH2:10][CH:11]([CH2:23][O:24][CH3:29])[N:12]2[S:13](=[O:14])(=[O:15])[c:16]2[cH:17][cH:18][c:19]([CH3:22])[cH:20][cH:21]2)[cH:6][cH:7]1

Participants

8

Reactant 7

HCID 923Sodium ionHCID 6328Methyl iodideHCID 8028TetrahydrofuranHCID 8058HexaneHCID 8857Ethyl AcetateHCID 166653HydrideHCID 22250435(2RS,5SR)-[5-(4-fluoro-phenyl)-1-(toluene-4-sulfonyl)-pyrrolidin-2-yl]-methanol

Product 1

HCID 22250537(2RS,5SR)-2-(4-Fluoro-phenyl)-5-methoxymethyl-1-(toluene-4-sulfonyl)-pyrrolidine

Sources & evidence

ORD record
ord-a765cfc90520445aa7d924f476dcec3f
Source dataset
Test data from https://doi.org/10.1039/C8SC04228D

Reaction notes

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