Trifluoroacetic acid → HCID 178521196, compound

HRID 813670Notes

Reaction equation

[CH2:55]([SiH:56]([CH2:57][CH3:58])[CH2:59][CH3:60])[CH3:61].[Cl:1][c:2]1[cH:3][n:4][c:5]([NH:44][CH2:45][C:46]([c:47]2[n:48][cH:49][cH:50][cH:51][cH:52]2)([F:53])[F:54])[c:6](=[O:43])[n:7]1[CH2:8][C:9](=[O:10])[NH:11][CH2:12][c:13]1[c:14](-[c:19]2[n:20][cH:21][n:22]([C:24]([c:25]3[cH:26][cH:27][cH:28][cH:29][cH:30]3)([c:31]3[cH:32][cH:33][cH:34][cH:35][cH:36]3)[c:37]3[cH:38][cH:39][cH:40][cH:41][cH:42]3)[cH:23]2)[cH:15][cH:16][cH:17][cH:18]1.[OH:62][C:63]([C:64]([F:65])([F:66])[F:67])=[O:68]>>[Cl:1][c:2]1[cH:3][n:4][c:5]([NH:44][CH2:45][C:46]([c:47]2[n:48][cH:49][cH:50][cH:51][cH:52]2)([F:53])[F:54])[c:6](=[O:43])[n:7]1[CH2:8][C:9](=[O:10])[NH:11][CH2:12][c:13]1[c:14](-[c:19]2[n:20][cH:21][nH:22][cH:23]2)[cH:15][cH:16][cH:17][cH:18]1

Participants

Reactant 3

HCID 6422Trifluoroacetic acid

HCID 12052Triethylsilane

HCID 221851502-[6-chloro-3-(2,2-difluoro-2-pyridin-2-yl-ethylamino)-2-oxo-2H-pyrazin-1-yl]-N-[2-(1-trityl-1H-imidazol-4-yl)-benzyl]-acetamide

Product 1

HCID 178521196HCID 178521196, compound

Sources & evidence

ORD record: ord-120e69bc59fe4fc296fd620a16dbc843
Source dataset: Test data from https://doi.org/10.1039/C8SC04228D
DOI: 10.1039/C8SC04228D

Reaction notes

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