反应详情

温度

80 °C

920 mg of tert-butyl (R)-2-{[(3-fluorophenyl)methylamino]methyl}pyrrolidine-1-carboxylate are dissolved in, 10 ml of THF, and 5 ml of ethanolic hydrochloric acid are added. The mixture is stirred at 80° C. for 4 h and, for work-up, partitioned between 50 ml of water and 50 ml of ethyl acetate at room temperature. Conventional work-up and purification by chromatography on silica gel gives 300 mg of (3-fluorophenyl)methyl-(R)-1-pyrrolidin-2-ylmethylamine; Rt.: 1.377 min; [M+H]+209.2.

1. additionare added
2. custompartitioned between 50 ml of water and 50 ml of ethyl acetate at room temperature
3. customConventional work-up and purification by chromatography on silica gel