反应详情

温度

80 °C

1 g of tert-butyl (R)-2-[(E)-2-(3-chlorophenyl)vinyl]pyrrolidine-1-carboxylate are dissolved in 10 ml of THF, and 5 ml of ethanolic hydrochloric acid are added. The mixture is stirred at 80° C. for 4 h and, for work-up, partitioned between 50 ml of water and 50 nil of ethyl acetate at room temperature. Conventional work-up and purification by chromatography on silica gel gives 750 mg of (R)-2-[(E)-2-(3-chlorophenyl)vinyl]pyrrolidine; Rt.: 1.554 min; [M+H]+208.2.

1. custompartitioned between 50 ml of water and 50 nil of ethyl acetate at room temperature
2. customConventional work-up and purification by chromatography on silica gel