Dimethylformamide → 2-(4-Chlorobenzyloxy)-3,3,3-trifluoro-2-trifluoromethylpropionitrile

HRID 814191Notes

Reaction equation

HRID 814191 reaction equation
[CH3:23][N:24]([CH3:25])[CH:26]=[O:27].[Cl:14][c:15]1[cH:16][cH:17][c:18]([CH2:19][Cl:20])[cH:21][cH:22]1.[Na:1].[OH:2][C:3]([C:4]#[N:5])([C:6]([F:7])([F:8])[F:9])[C:10]([F:11])([F:12])[F:13]>>[O:2]([C:3]([C:4]#[N:5])([C:6]([F:7])([F:8])[F:9])[C:10]([F:11])([F:12])[F:13])[CH2:19][c:18]1[cH:17][cH:16][c:15]([Cl:14])[cH:22][cH:21]1

Participants

5

Reactant 4

HCID 6228DimethylformamideHCID 77231-Chloro-4-(chloromethyl)benzeneHCID 5360545SodiumHCID 203144733,3,3-Trifluoro-2-hydroxy-2-(trifluoromethyl)propanenitrile

Product 1

HCID 133842982-(4-Chlorobenzyloxy)-3,3,3-trifluoro-2-trifluoromethylpropionitrile

Sources & evidence

ORD record
ord-4c1fbee49dfa46e09688e4f44ab9c07b
Source dataset
Test data from https://doi.org/10.1039/C8SC04228D

Reaction notes

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