m-Bromobenzenesulphonyl chloride → 1-(3-Bromobenzenesulfonyl)-4-methylpiperazine

HRID 81482Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 81482
[CH3:1][N:2]1[CH2:7][CH2:6][NH:5][CH2:4][CH2:3]1.[Br:8][C:9]1[CH:10]=[C:11]([S:15](Cl)(=[O:17])=[O:16])[CH:12]=[CH:13][CH:14]=1>N1C=CC=CC=1.Cl>[Br:8][C:9]1[CH:10]=[C:11]([S:15]([N:5]2[CH2:6][CH2:7][N:2]([CH3:1])[CH2:3][CH2:4]2)(=[O:17])=[O:16])[CH:12]=[CH:13][CH:14]=1

Komponenten

5

Edukt 2

HCID 17943m-Bromobenzenesulphonyl chlorideHCID 531671-Methylpiperazine

Produkt 1

HCID 294021141-(3-Bromobenzenesulfonyl)-4-methylpiperazine

Reagenzien, Katalysatoren, Lösungsmittel 2

HCID 313Hydrochloric AcidLösungsmittelHCID 1049PyridineLösungsmittel

Versuchsvorschrift

A solution of 1-methylpiperazine (0.072 ml, 0.65 mmol) and 3-bromobenzene-1-sulfonyl chloride (0.2 g, 0.78 mmol) in pyridine (3 ml) is stirred at room temperature for 2 hours. The reaction mixture is diluted with 2M HCl, and extracted with DCM. The aqueous layer is made basic with 2M NaOH, and is extracted with DCM. The DCM layers are combined, dried (MgSO4) and the solvent removed in vacuo to afford the title compound as an orange oil. [M+H]+ 345.

Aufarbeitung

  1. extractionextracted with DCM
  2. extractionis extracted with DCM
  3. dry with materialdried (MgSO4)
  4. customthe solvent removed in vacuo

Quellen und Nachweise

ORD-Eintrag
ord-c748f04c3b984371bea84924a0a5c617
Quelldatensatz
uspto-grants-2014_09
Patentnummer
US08846687B2

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