Hydrochloric Acid → HCID 178490494, compound

HRID 81498Notes

Reaction equation

HRID 81498 reaction equation
[OH:1][C:2]1[C:7]([NH:8][C:9](=[O:20])[C:10]2[CH:15]=[C:14]([CH3:16])[C:13]([O:17][CH3:18])=[C:12]([CH3:19])[CH:11]=2)=[C:6]([OH:21])[N:5]=[C:4]([S-:22])[N:3]=1.[Na+].[OH-].[Na+].I[CH3:27].Cl>O.CN1CCCC1=O>[OH:21][C:6]1[C:7]([NH:8][C:9](=[O:20])[C:10]2[CH:11]=[C:12]([CH3:19])[C:13]([O:17][CH3:18])=[C:14]([CH3:16])[CH:15]=2)=[C:2]([OH:1])[N:3]=[C:4]([S:22][CH3:27])[N:5]=1

Participants

7

Reactant 4

HCID 313Hydrochloric AcidHCID 6328Methyl iodideHCID 14798Sodium HydroxideHCID 178490495HCID 178490495, compound

Product 1

HCID 178490494HCID 178490494, compound

Reagents, catalysts & solvents 2

HCID 962WaterSolventHCID 13387N-methyl-2-pyrrolidoneSolvent2×

Conditions

Temperature
0 °C

Procedure

19.1 g of sodium 4,6-dihydroxy-5-(4-methoxy-3,5-dimethylbenzoylamino)pyrimidine-2-thiolate in 190 ml of water and 80 ml of N-methylpyrrolidin-2-one were cooled to 0° C. With cooling, 5.9 g of sodium hydroxide were added, after which the mixture was stirred at 0° C. for 30 min. A solution of 3.7 ml of iodomethane in 4.3 ml of N-methylpyrrolidin-2-one was then added. After the reaction had ended (2 h), the mixture was acidified with concentrated hydrochloric acid. The precipitate obtained was filtered off with suction, washed with water and dried under reduced pressure. This gave 10.1 g of the title compound.

Workup

  1. temperatureWith cooling
  2. custom(2 h)
  3. customThe precipitate obtained
  4. filtrationwas filtered off with suction
  5. washwashed with water
  6. customdried under reduced pressure

Sources & evidence

ORD record
ord-8bafcd1844bb40fd83c6eb4085192a5b
Source dataset
uspto-grants-2014_09
Patent number
US08846691B2

Reaction notes

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