Dichloromethane → 4-Amino-2-chloronicotinaldehyde

HRID 815967Notes

Reaction equation

HRID 815967 reaction equation
[C:28]([O:29][CH3:30])([CH3:31])([CH3:32])[CH3:33].[Cl:25][CH2:26][Cl:27].[Cl:8][c:9]1[n:10][cH:11][cH:12][c:13]([NH:17][C:18](=[O:19])[O:20][C:21]([CH3:22])([CH3:23])[CH3:24])[c:14]1[CH:15]=[O:16].[OH:1][C:2]([C:3]([F:4])([F:5])[F:6])=[O:7]>>[Cl:8][c:9]1[n:10][cH:11][cH:12][c:13]([NH2:17])[c:14]1[CH:15]=[O:16]

Participants

5

Reactant 4

HCID 6344DichloromethaneHCID 6422Trifluoroacetic acidHCID 15413tert-Butyl methyl etherHCID 52987944tert-Butyl (2-chloro-3-formylpyridin-4-yl)carbamate

Product 1

HCID 454898674-Amino-2-chloronicotinaldehyde

Sources & evidence

ORD record
ord-33d89cab038e460489a9921af47aec82
Source dataset
Test data from https://doi.org/10.1039/C8SC04228D

Reaction notes

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