Acetonitrile → tert-Butyl 4-(2-chloropyrimidin-4-yloxy)naphthalen-1-ylcarbamate

HRID 816009Notes

Reaction equation

HRID 816009 reaction equation
[CH2:20]1[CH2:21][CH2:22][C:23]2=[N:28][CH2:27][CH2:26][CH2:25][N:24]2[CH2:29][CH2:30]1.[CH3:39][C:40]#[N:41].[Cl:31][c:32]1[n:33][cH:34][cH:35][c:36]([Cl:38])[n:37]1.[OH:1][c:2]1[cH:3][cH:4][c:5]([NH:12][C:13]([O:14][C:15]([CH3:16])([CH3:17])[CH3:18])=[O:19])[c:6]2[cH:7][cH:8][cH:9][cH:10][c:11]12>>[O:1]([c:2]1[cH:3][cH:4][c:5]([NH:12][C:13]([O:14][C:15]([CH3:16])([CH3:17])[CH3:18])=[O:19])[c:6]2[cH:7][cH:8][cH:9][cH:10][c:11]12)[c:36]1[cH:35][cH:34][n:33][c:32]([Cl:31])[n:37]1

Participants

5

Reactant 4

HCID 6342AcetonitrileHCID 775312,4-DichloropyrimidineHCID 811841,8-Diazabicyclo(5.4.0)undec-7-eneHCID 10923237tert-Butyl (4-hydroxynaphthalen-1-yl)carbamate

Product 1

HCID 86660490tert-Butyl 4-(2-chloropyrimidin-4-yloxy)naphthalen-1-ylcarbamate

Sources & evidence

ORD record
ord-f8d5ae36562f4aa9a5d5c7878bfca640
Source dataset
Test data from https://doi.org/10.1039/C8SC04228D

Reaction notes

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