Ammonium → (2-methylsulfanyl-pyrimidin-5-yl)-(7-triisopropylsilanyl-7H-pyrrolo[2,3-d]pyrimidin-5-yl)-methanol

HRID 817407Notes

Reaction equation

HRID 817407 reaction equation
[CH3:26][S:27][c:28]1[n:29][cH:30][c:31]([CH:34]=[O:35])[cH:32][n:33]1.[CH:22]([Mg+:23])([CH3:24])[CH3:25].[Cl-:21].[Cl-:36].[I:1][c:2]1[cH:3][n:4]([Si:11]([CH:12]([CH3:13])[CH3:14])([CH:15]([CH3:16])[CH3:17])[CH:18]([CH3:19])[CH3:20])[c:5]2[n:6][cH:7][n:8][cH:9][c:10]12.[NH4+:37].[O:38]1[CH2:39][CH2:40][CH2:41][CH2:42]1>>[c:2]1([CH:34]([c:31]2[cH:30][n:29][c:28]([S:27][CH3:26])[n:33][cH:32]2)[OH:35])[cH:3][n:4]([Si:11]([CH:12]([CH3:13])[CH3:14])([CH:15]([CH3:16])[CH3:17])[CH:18]([CH3:19])[CH3:20])[c:5]2[n:6][cH:7][n:8][cH:9][c:10]12

Participants

7

Reactant 6

HCID 223AmmoniumHCID 312Chloride2×HCID 8028TetrahydrofuranHCID 31518652-(Methylthio)-5-pyrimidinecarbaldehydeHCID 509865195-Iodo-7-(triisopropylsilyl)-7H-pyrrolo-[2,3-d]pyrimidineHCID 178461726HCID 178461726, compound

Product 1

HCID 57963217(2-methylsulfanyl-pyrimidin-5-yl)-(7-triisopropylsilanyl-7H-pyrrolo[2,3-d]pyrimidin-5-yl)-methanol

Sources & evidence

ORD record
ord-e63862b20fcf45a48f48ca54a938aefa
Source dataset
Test data from https://doi.org/10.1039/C8SC04228D

Reaction notes

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