N-methyl-2-pyrrolidone → 7-[3-[[4-[5-(Acetamidomethyl)-2-oxo-1,3-oxazolidin-3-yl]-2-fluorophenoxy]methyl]-3-hydroxypyrrolidin-1-yl]-1-cyclopropyl-6-fluoro-8-methoxy-4-oxoquinoline-3-carboxylic acid
Reaction equation
[C:27]([O:28][B:29]([OH:30])[O:31][C:32](=[O:33])[CH3:34])(=[O:35])[CH3:36].[CH2:58]([N:59]([CH:60]([CH3:61])[CH3:62])[CH:63]([CH3:64])[CH3:65])[CH3:66].[CH3:67][N:68]1[CH2:69][CH2:70][CH2:71][C:72]1=[O:73].[CH:37]1([n:40]2[cH:41][c:42]([C:55](=[O:56])[OH:57])[c:43](=[O:54])[c:44]3[cH:45][c:46]([F:53])[c:47]([F:52])[c:48]([O:50][CH3:51])[c:49]23)[CH2:38][CH2:39]1.[F:1][c:2]1[cH:3][c:4]([N:16]2[C:17](=[O:26])[O:18][CH:19]([CH2:21][NH:22][C:23]([CH3:24])=[O:25])[CH2:20]2)[cH:5][cH:6][c:7]1[O:8][CH2:9][C:10]1([OH:15])[CH2:11][NH:12][CH2:13][CH2:14]1>>[F:1][c:2]1[cH:3][c:4]([N:16]2[C:17](=[O:26])[O:18][CH:19]([CH2:21][NH:22][C:23]([CH3:24])=[O:25])[CH2:20]2)[cH:5][cH:6][c:7]1[O:8][CH2:9][C:10]1([OH:15])[CH2:11][N:12]([c:47]2[c:46]([F:53])[cH:45][c:44]3[c:43](=[O:54])[c:42]([C:55](=[O:56])[OH:57])[cH:41][n:40]([CH:37]4[CH2:38][CH2:39]4)[c:49]3[c:48]2[O:50][CH3:51])[CH2:13][CH2:14]1Participants
6
Reactant 5
HCID 13387N-methyl-2-pyrrolidone
HCID 81531Diisopropylethylamine
HCID 70194651-Cyclopropyl-6,7-difluoro-1,4-dihydro-8-methoxy-4-oxo-3-quinolinecarboxylic acid
HCID 67279370Diacetyloxyborinic acid
HCID 118524610N-[[3-[3-fluoro-4-[(3-hydroxypyrrolidin-3-yl)methoxy]phenyl]-2-oxo-1,3-oxazolidin-5-yl]methyl]acetamideProduct 1
Sources & evidence
- ORD record
- ord-22b32ea52b554001829fd527e7aed67f
- Source dataset
- Test data from https://doi.org/10.1039/C8SC04228D
Reaction notes
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